Réaction #74500

Équation de réaction

3-bromo-1,8-naphthalic anhydride

compound 74

3-bromo-1,8-naphthalic anhydride

sodium hydroxide

→

3-Bromo-1-naphthoic acid

Solvants

water

water

acetic acid

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture was heated
2. 2
   Températureat reflux for 4 days
3. 3
   FiltrationThe resulting solid was filtered
4. 4
   Autredried in vacuo

Mode opératoire

To a mixture of 3-bromo-1,8-naphthalic anhydride (compound 74, 22.8 g, 82.4 mmol) and sodium hydroxide (13.2 g, 330 mmol) in water (500 mL) was added a solution of mercury(II) oxide (23.2 g, 107 mmol) in water (70 mL) and glacial acetic acid (24 mL). The reaction mixture was heated at reflux for 4 days and then cooled to room temperature. The resulting solid was filtered and dried in vacuo.

Source