Réaction #742252

Équation de réaction

3-(2-hydroxy-phenyl)-acrylic acid ethyl ester

dec-9-en-1-ol

→

colourless crystals

Rendement 21.5%

(E)-3-(2-Hydroxy-phenyl)-acrylic acid dec-9-enyl ester

Rendement 21.5%

Solvants

ether

Conditions de réaction

Traitement

1. 1
   Autreremoving the ethanol
2. 2
   Autreformed
3. 3
   Températurethe reaction mixture was cooled
4. 4
   Lavagewashed with brine
5. 5
   AutreThe organic phase was dried
6. 6
   Autreevaporated to dryness
7. 7
   workup.DISTILLATIONThe resulting oil was Kugelrohr-distilled
8. 8
   Autrecrystallized
9. 9
   Autrerecrystallized

Mode opératoire

A mixture of 5.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester, 6.1 g dec-9-en-1-ol and 1.0 g tetraisopropyl-ortho-titanate was heated to 150° C. removing the ethanol formed. After stirring for 2.5 hours at this temperature, the reaction mixture was cooled, diluted with ether and washed with brine. The organic phase was dried and evaporated to dryness. The resulting oil was Kugelrohr-distilled, crystallized and recrystallized to yield 1.69 g of colourless crystals.

Source