Réaction #742249

Équation de réaction

ethoxycarbonylmethylenetriphenylphosphorane

toluene

1-(4-diethylamino-2-hydroxy-phenyl)ethanone

→

3(4-Diethylamino-2-hydroxy-phenyl)-but-2-enoic acid ethyl ester

Conditions de réaction

Traitement

1. 1
   TempératureThen the reaction mixture was heated to reflux
2. 2
   TempératureAfter refluxing for 31 hours the mixture
3. 3
   Températurewas cooled down
4. 4
   Autreevaporated to dryness
5. 5
   AutreThe resulting dark oil was purified by chromatography
6. 6
   Autreto yield a colourless oil

Mode opératoire

To a suspension of 5.27 g ethoxycarbonylmethylenetriphenylphosphorane in 10 ml of toluene, a solution of 2.02 g 1-(4-diethylamino-2-hydroxy-phenyl)ethanone (DE 28 44 606) was dropped in at room temperature. Then the reaction mixture was heated to reflux. After refluxing for 31 hours the mixture was cooled down and evaporated to dryness. The resulting dark oil was purified by chromatography to yield a colourless oil.

Source