Réaction #73902

Équation de réaction

methyl N-[1-(benzofuran-5-yl)-2-(dimethylamino)-2-oxoethyl]-L-leucinate

lithium hydroxide

→

N-[1-(benzofuran-5-yl)-2-(dimethylamino)-2-oxoethyl]-L-leucine

Rendement 95.8%

Solvants

methanol

water

Conditions de réaction

Traitement

1. 1
   Autrewas removed in vacuo
2. 2
   workup.ADDITIONThe residue was diluted with water (10 ml)
3. 3
   Lavageeluted with water (×2) and methanol (×2)
4. 4
   Autreevaporated

Mode opératoire

To a solution of methyl N-[1-(benzofuran-5-yl)-2-(dimethylamino)-2-oxoethyl]-L-leucinate (520 mg) in methanol (5 ml) was added a solution of lithium hydroxide (91 mg) in water (3 ml). After stirring vigorously for 24 hours the solvent was removed in vacuo. The residue was diluted with water (10 ml) then neutralised with 2N hydrochloric acid. This solution was applied to an Oasis™ cartridge (2×6 g) and eluted with water (×2) and methanol (×2). The required fractions were combined and evaporated to afford N-[1-(benzofuran-5-yl)-2-(dimethylamino)-2-oxoethyl]-L-leucine (478 mg).

Source