Réaction #7389

Équation de réaction

5-chloro-1-benzofuran-2-carboxylic acid

→

title compound

5-Chloro-1-benzofuran

Solvants

1-methyl-2-pyrrolidinone

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction vessel was cooled to room temperature
2. 2
   Autrethe combined mixtures partitioned between water and diethyl ether
3. 3
   LavageThe organic layer was washed with water and brine
4. 4
   Séchagedried (over magnesium sulphate)
5. 5
   Concentrationconcentrated under reduced pressure

Mode opératoire

To a solution of 5-chloro-1-benzofuran-2-carboxylic acid (0.2 g) in 1-methyl-2-pyrrolidinone (2 ml) was added copper granules (0.2 g). The reaction mixture was heated at 250° C. for 3.5 min in a microwave. The reaction vessel was cooled to room temperature and the mixture combined with four other similar mixtures and the combined mixtures partitioned between water and diethyl ether. The organic layer was washed with water and brine, dried (over magnesium sulphate) and concentrated under reduced pressure to give the title compound (0.65 g) as a yellow oil.

Source