Réaction #73358

Équation de réaction

4-[benzyl-(1-ethoxycarbonyl-ethyl)-amino]-butyric acid methyl ester

potassium tert-butoxide

→

(±)-1-Benzyl-2-methyl-3-oxo-piperidine-4-carboxylic acid methyl ester

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   AutreThe mixture is then partitioned between DCM and saturated aqueous NH4Cl
2. 2
   AutreThe organic layer is removed
3. 3
   Séchagedried over anhydrous Na2SO4
4. 4
   Concentrationconcentrated
5. 5
   AutreThe crude residue is used without further purification

Mode opératoire

A mixture of 4-[benzyl-(1-ethoxycarbonyl-ethyl)-amino]-butyric acid methyl ester (1.5 g, 4.9 mmol), potassium tert-butoxide (906 mg, 8.9 mmol) and toluene (100 mL) is stirred at rt for 3 h. The mixture is then partitioned between DCM and saturated aqueous NH4Cl. The organic layer is removed, dried over anhydrous Na2SO4, and concentrated. The crude residue is used without further purification.

Source