Réaction #73119

ord-988719acb43740549bfb3aea81d62194

Équation de réaction

CC[C@@H]1C(=O)N(C)c2cnc(-n3cnc(C(=O)O)c3)nc2N1C1CCCC1
(R)-1-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-imidazole-4-carboxylic acid
CC(=O)[O-].[NH4+]
ammonium acetate
→
CC[C@@H]1C(=O)N(C)c2cnc(-n3cnc(C(N)=O)c3)nc2N1C1CCCC1
title compound
CC[C@@H]1C(=O)N(C)c2cnc(-n3cnc(C(N)=O)c3)nc2N1C1CCCC1
(R)-1-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-imidazole-4-carboxamide

Réactifs

CC[C@@H]1C(=O)N(C)c2cnc(-n3cnc(C(=O)O)c3)nc2N1C1CCCC1
(R)-1-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-imidazole-4-carboxylic acid
CC(=O)[O-].[NH4+]
ammonium acetate

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The title compound was prepared similarly to the methods described in Example 39, with (R)-1-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-imidazole-4-carboxylic acid (Example 37) used instead of (R)-1-(8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-pyrazole-4-carboxylic acid (Example 44) and ammonium acetate instead of dimethylamine hydrochloride. LCMS: 370.2 m/z (M+H)+; ret. Time: 3.97 (Analytical Method D).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08541418B2uspto-grants-2013_09