Réaction #7300

Équation de réaction

hydrogen

oxygen

hydrogen

Tetrafluoroboric acid

3-(2-acetylamino-2-methoxycarbonylvinyl)pyridinium tetrafluoroborate

→

title compound

Rendement 99.1%

(S)-3-(2-Acetylamino-2-methoxycarbonylethyl)pyridinium tetrafluoroborate

Rendement 99.1%

Solvants

methanol

methanol

Conditions de réaction

Traitement

1. 1
   Autrethe autoclave was closed
2. 2
   AutreThe catalyst solution was prepared
3. 3
   workup.ADDITIONwhile introducing argon
4. 4
   AutreWith exclusion of air, the methanol degassed in this manner
5. 5
   Autrethe yellow-orange catalyst solution was sonicated under argon for 30 min
6. 6
   Autrewas hydrogenated at 50° C., with vigorous stirring
7. 7
   workup.WAITAfter 7 h

Mode opératoire

In an autoclave, 3-(2-acetylamino-2-methoxycarbonylvinyl)pyridinium tetrafluoroborate (10.3 kg, 33.44 mol) was dissolved in methanol (120.0 l). Tetrafluoroboric acid solution (50% in water, 1.018 kg, 5.8 mol) was added, and the autoclave was closed and carefully inertized using nitrogen. The catalyst solution was prepared by treating methanol (3.0 l) in an ultrasonic bath for 15 min while introducing argon. With exclusion of air, the methanol degassed in this manner was admixed with (+)-phenyl-CAPP (12.5 g, 20.83 mmol) and [Rh(COD)Cl]2 (5.0 g, 10.10 mmol), and the yellow-orange catalyst solution was sonicated under argon for 30 min. With exclusion of oxygen, the catalyst solution was introduced into the autoclave. Within a period of 1 h, the contents of the autoclave was heated to 40° C. In each case about 3 bar of hydrogen were applied three times, and the autoclave was vented immediately again. 1.5 bar of hydrogen were then applied, and the mixture was hydrogenated at 50° C., with vigorous stirring. After 7 h, the hydrogenation stopped. The HPLC analysis of a sample taken showed that, at this point in time, 99.1% of the title compound was present, and GC analysis (30 m fused silica capillary column Chirasil Val, isothermic 160° C., injector 220° C., detector (FID) 260° C., carrier gas 0.8 bar of hydrogen, tret [(R) enantiomer] 12.64 min, tret [(S) enantiomer] 13.64 min) showed that the enantiomeric purity was 86% ee of (S) isomer. The autoclave was flushed with nitrogen and, using nitrogen, the contents of the autoclave were pressed through a Seitz filter into a vessel, where the filtrate was stored at +5° C. under nitrogen.

Source