Réaction #729820

ord-9cbc1e0f2b2d4749a50cd0b731b5a34b

Équation de réaction

CCOC(=O)Cc1c(C(=O)OCC)[nH]c2ccc(F)cc12
3-ethoxycarbonylmethyl-5-fluoro-1H-indole-2-carboxylic acid ethyl ester
BrCc1cccc2ccccc12
1-bromomethyl-naphthalene
→
O=C(O)Cc1c(C(=O)O)n(Cc2cccc3ccccc23)c2ccc(F)cc12
title compound
O=C(O)Cc1c(C(=O)O)n(Cc2cccc3ccccc23)c2ccc(F)cc12
3-Carboxymethyl-5-fluoro-1-naphthalen-1-ylmethyl-1H-indole-2-carboxylic acid

Réactifs

CCOC(=O)Cc1c(C(=O)OCC)[nH]c2ccc(F)cc12
3-ethoxycarbonylmethyl-5-fluoro-1H-indole-2-carboxylic acid ethyl ester
BrCc1cccc2ccccc12
1-bromomethyl-naphthalene

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    Autrethe product obtained

Mode opératoire

Using general procedure B, 3-ethoxycarbonylmethyl-5-fluoro-1H-indole-2-carboxylic acid ethyl ester (Lit. 10) was coupled with 1-bromomethyl-naphthalene and the product obtained was hydrolyzed to give the title compound as a white solid. MS: 376.4 ([M−H]−).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07696240B2uspto-grants-2010_04