Réaction #72925

Équation de réaction

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

diethylether

→

title compound

Rendement 92.0%

N′-(1-acetylpiperidin-4-yl)benzohydrazide

Rendement 92.0%

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   FiltrationThe catalyst was then filtered on celite
2. 2
   Autrethe filtrate evaporated in vacuo
3. 3
   workup.DISSOLUTIONThe residue was redissolved with dichloromethane
4. 4
   Lavagewashed with aqueous NaHCO3
5. 5
   SéchageThe solvent was dried over sodium sulfate
6. 6
   Autreremoved under reduced pressure
7. 7
   Autreto give

Mode opératoire

30 g (0.12 mol) of N′-(1-acetylpiperidin-4-ylidene)benzohydrazide were dissolved in 500 mL of glacial acetic acid and 1 g of PtO2 were added. The mixture was hydrogenated at 40 psi for 12 hours at room temperature. The catalyst was then filtered on celite and the filtrate evaporated in vacuo. The residue was redissolved with dichloromethane and washed with aqueous NaHCO3. The solvent was dried over sodium sulfate and removed under reduced pressure to give, after trituration with diethylether, 28.6 g (92% yield) of the title compound.

Source