Réaction #72924

Équation de réaction

diethylether

1-acetyl-4-piperidone

benzoylhydrazine

→

title compound

Rendement 83.0%

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

Rendement 83.0%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   TempératureThe resulting solution was refluxed for 6 hours
2. 2
   AutreThe solvent was then removed in vacuo
3. 3
   Autrethe residue partitioned between dichloromethane and water
4. 4
   SéchageThe organic layer was dried over sodium sulfate
5. 5
   Autreevaporated to dryness

Mode opératoire

20 g (0.142 mol) of 1-acetyl-4-piperidone were dissolved in 400 mL of absolute ethanol and 21.2 g (0.156 mol) of benzoylhydrazine were added. The resulting solution was refluxed for 6 hours under stirring. The solvent was then removed in vacuo and the residue partitioned between dichloromethane and water. The organic layer was dried over sodium sulfate and evaporated to dryness. The residue was triturated with diethylether and 30 g (83% yield) of the title compound were collected by filtration.

Source