Réaction #725922

Équation de réaction

6-(4-nitrophenoxy) hexanoic acid methyl ester

6-(4-Nitro-phenoxy)-hexanoic acid methyl ester

→

53

Rendement 80.2%

6-(4-Nitrophenoxy)-hexanoic acid

Rendement 80.2%

Solvants

HCl

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 16 hours
2. 2
   Filtrationfiltered
3. 3
   Autredried
4. 4
   Autrerecrystallised from a mixture of ethyl acetate:hexane (1:6)

Mode opératoire

A mixture of 6-(4-nitrophenoxy) hexanoic acid methyl ester 39 (125 g, 468.16 mmol) and concentrated HCl (1250 ml) was refluxed for 16 hours. The reaction mixture was cooled to room temperature, filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 53 (95 g, 80.2%) as a white powder. M.p: 104-107° C.

Source