Réaction #725918

Équation de réaction

2-(4-Nitro-phenoxy)-propionic acid

ethylene glycol

HCl

→

48

Rendement 56.8%

2-(4-Nitro-phenoxy)-propionic acid 2-hydroxy-ethyl ester

Rendement 56.8%

Solvants

water

Conditions de réaction

Traitement

1. 1
   Autrefor 1½ hours
2. 2
   AutreDuring HCl gas bubbling the temp
3. 3
   Autrerose to 60° C
4. 4
   AutreThe crude reaction mass
5. 5
   ExtractionCrude 48 was extracted into chloroform
6. 6
   Séchagedried over Na2SO4
7. 7
   workup.DISTILLATIONdistilled
8. 8
   Autrepurified by column chromatography on silica gel

Mode opératoire

To a mixture of 2-(4-Nitro-phenoxy)-propionic acid 47 (45 g, 213 mol) and ethylene glycol (135 ml) was passed dry HCl gas for 1½ hours. During HCl gas bubbling the temp. rose to 60° C. The crude reaction mass was poured onto cold water (600 ml). Crude 48 was extracted into chloroform, dried over Na2SO4, distilled and purified by column chromatography on silica gel using hexane as eluant to give pure 48 (28 g, 56.8%) as a syrup.

Source