Réaction #725898

Équation de réaction

Benzyloxyacetic acid 4-acetylamino-phenyl ester

Benzyloxy-acetic acid 4-acetylamino-phenyl ester

→

25

Rendement 57.4%

Hydroxy-acetic acid 4-acetylamino-phenyl ester

Rendement 57.4%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   AutreThe catalyst was removed by filtration
2. 2
   workup.DISTILLATIONthe methanol was then distilled off
3. 3
   AutreThe crude 25 was recrystallized from mixture of chloroform:methanol (1:4)

Mode opératoire

Benzyloxyacetic acid 4-acetylamino-phenyl ester 24 (15 g, 50 mmol) was dissolved in methanol (150 ml) in a pressure vessel, palladium on carbon (5%, 8 grams) added and the mixture stirred under an atmosphere of hydrogen (3 Kg) for 20 hours. The catalyst was removed by filtration and the methanol was then distilled off. The crude 25 was recrystallized from mixture of chloroform:methanol (1:4) to get pure 25 (6 g, 57.2%) as a white powder. M.p: 144-146° C.

Source