Réaction #7221

Équation de réaction

N-benzimidazolyl-1,2-propanediol

sodium periodate

→

2-(benzimidazol-1-yl)-ethanal

Rendement 41.2%

Solvants

water

Conditions de réaction

Traitement

1. 1
   ExtractionThe solution was then extracted with dichloromethane
2. 2
   Séchagedried (MgSO4)
3. 3
   Filtrationfiltered
4. 4
   Concentrationconcentrated

Mode opératoire

The intermediate, N-benzimidazolyl-1,2-propanediol (0.66 g, 3.4 mmol) from above was dissolved in water (25 mL) and treated with sodium periodate (0.88 g, 4.1 mmol) with stirring for 1.5 hours. The solution was then extracted with dichloromethane, dried (MgSO4), filtered and concentrated to yield 2-(benzimidazol-1-yl)-ethanal (0.22 g, 1.4 mmol) which was used immediately without further purification in the next reaction.

Source