Réaction #72195

ord-d3beea6e4def4d39ae80f2382e9a50cc

Équation de réaction

CC[C@H](Br)[C@H]1CO1
(2R*)-2-[(1S*)-1-bromopropyl]oxirane
NC(c1ccccc1)c1ccccc1
benzhydrylamine
→
CC[C@H]1[C@@H](O)CN1C(c1ccccc1)c1ccccc1
title compound
Rendement 29.0%
CC[C@H]1[C@@H](O)CN1C(c1ccccc1)c1ccccc1
cis(±)-1-(Diphenylmethyl)-2-ethylazetidin-3-ol
Rendement 29.0%

Réactifs

CC[C@H](Br)[C@H]1CO1
(2R*)-2-[(1S*)-1-bromopropyl]oxirane
NC(c1ccccc1)c1ccccc1
benzhydrylamine

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The same operation as in Example (234b) was performed using (2R*)-2-[(1S*)-1-bromopropyl]oxirane obtained in Example (235a) (1.50 g, 9.09 mmol) and benzhydrylamine (1.57 mL, 9.09 mmol), to obtain 699 mg of the title compound as a pale yellow solid (29%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08536197B2uspto-grants-2013_09