Réaction #72145

Équation de réaction

sodium carbonate

tert-butyl cis(±)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-(cyclopropylamino)piperidine-1-carboxylate

hydrochloric acid 1,4-dioxane

ethyl 2-bromo-1,3-benzothiazole-7-carboxylate

→

title compound

Rendement 26.0%

Ethyl cis(±)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-(cyclopropylamino)piperidin-1-yl)-1,3-benzothiazole-7-carboxylate

Rendement 26.0%

Conditions de réaction

Mode opératoire

The same operation as in Example (196c) was performed using tert-butyl cis(±)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-(cyclopropylamino)piperidine-1-carboxylate obtained in Example (213a) (34.0 mg, 0.083 mmol), 4 N hydrochloric acid/1,4-dioxane (2 mL), ethyl 2-bromo-1,3-benzothiazole-7-carboxylate obtained in Example (1f) (26 mg, 0.091 mmol) and sodium carbonate (87 mg, 0.825 mmol), to obtain 11 mg of the title compound (26%) as a pale yellow oily substance.

Source