Réaction #72001

Équation de réaction

cis(±)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride

2-chloropyrimidine

sodium carbonate

→

title compound

Rendement 22.3%

cis(±)-4-Chloro-N-(3-ethoxy-1-pyrimidin-2-ylpiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide

Rendement 22.3%

Solvants

DMF

Conditions de réaction

Mode opératoire

cis(±)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride obtained in Example (131a) (100 mg, 0.297 mmol), 2-chloropyrimidine (51 mg, 0.45 mmol) and sodium carbonate (157 mg, 1.48 mmol) were suspended in DMF (1 mL). The suspension was subjected to the same operation as in Example (131b) to obtain 25.1 mg of the title compound as a white solid (22%).

Source