Réaction #71968

Équation de réaction

3-(2,2-difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-one

3-(2,2-Difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-one

benzylamine

sodium (triacetoxy)borohydride

→

title compound

Rendement 79.2%

cis(±)-N-benzyl-3-(2,2-difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-amine

Rendement 79.2%

Solvants

1,2-dichloroethane

Conditions de réaction

Traitement

1. 1
   AutreThe resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=4/1, 1/1, 1/3, 0/1)

Mode opératoire

The same operation as in Example (90c) was performed using 3-(2,2-difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-one obtained in Example (121c) (1.1 g, 4 mmol), benzylamine (0.54 g, 5 mmol), sodium (triacetoxy)borohydride (0.85 g, 6 mmol) and 1,2-dichloroethane (15 mL). The resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=4/1, 1/1, 1/3, 0/1) to obtain 1.16 g of the title compound as a yellow oily substance (79%).

Source