Réaction #716038

Équation de réaction

Ethyl piperidine-4-carboxylate

2-chloro-6-methoxyquinoline

Intermediate 1

2-chloro-6-methoxyquinoline

MeCN

→

ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate

Conditions de réaction

Traitement

1. 1
   AutreAfter aqueous work-up with EtOAc and column purification
2. 2
   Lavageeluting with EtOAc/hexane

Mode opératoire

Ethyl piperidine-4-carboxylate (100 mg) was treated with 2-chloro-6-methoxyquinoline (Intermediate 1) (90 mg) in MeCN (0.8 mL) and TEA (100 mg) in a sealed tube at 180° C. for 6 h in a microwave reactor. After aqueous work-up with EtOAc and column purification, eluting with EtOAc/hexane, ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate (90 mg) was afforded as a solid.

Source