Réaction #71453

Équation de réaction

4-(2-nitro-1H-imidazol-4-ylmethyl)-piperazin-2-one

8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester

MeOH THF

MeOH

→

Title compound

8-(2,6-Difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [4-(3-oxo-piperazin-1-ylmethyl)-1H-imidazol-2-yl]-amide

Solvants

DCM MeOH

Conditions de réaction

Traitement

1. 1
   AutreThe title compound was prepared in analogy to the procedures

Mode opératoire

The title compound was prepared in analogy to the procedures described in Example 14 but using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 124.1), Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2, and 4-(2-nitro-1H-imidazol-4-ylmethyl)-piperazin-2-one (Step 142.1) instead of 2-nitroimidazole in Step 14.3. Title compound: ESI-MS: 524.1 [M+H]+; tR=3.10 min (System 1); TLC: Rf=0.23 (DCM/MeOH, 9:1).

Source