Réaction #71450

Équation de réaction

8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester

1-(2-dimethylamino-ethyl)-1H-pyrrol-3-ylamine

→

Title compound

8-(2,6-Difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [1-(2-dimethylamino-ethyl)-1H-pyrrol-3-yl]-amide

Solvants

DCM MeOH

Conditions de réaction

Traitement

1. 1
   AutreThe title compound was prepared in analogy to the procedure

Mode opératoire

The title compound was prepared in analogy to the procedure described in Step 14.1 but using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 124.1), 1-(2-dimethylamino-ethyl)-1H-pyrrol-3-ylamine (Step 121.1) and stirring the reaction mixture for 14 h at rt. Title compound: ESI-MS: 482.1 [M+H]+; tR=3.66 min (System 1); TLC: Rf=0.21 (DCM/MeOH, 9:1).

Source