Réaction #710507

Équation de réaction

NH4Cl

2-adamantone

CH3Li

→

56

Rendement 95.0%

2-methyl-2-adamantol

Rendement 95.0%

Solvants

ether

Conditions de réaction

Traitement

1. 1
   Autrebrought to ambient temperature
2. 2
   workup.STIRRINGstirred overnight
3. 3
   Extractionextracted with ether for three times
4. 4
   SéchageThe combined ether was dried over MgSO4
5. 5
   Concentrationconcentrated in vacuo
6. 6
   AutreThe crude residue was separated by flash column chromatography (CH2Cl2 to 5% CH3OH/CH2Cl2)

Mode opératoire

To a solution of 2-adamantone (1.50 g, 10 mmol) in ether was added CH3Li (7.5 ml, 1.6M in ether, 12 mmol) dropwise at 0° C. under a N2 atmosphere. The mixture was stirred for another hr at 0° C., then brought to ambient temperature and stirred overnight. Saturated NH4Cl solution was added and extracted with ether for three times. The combined ether was dried over MgSO4 and concentrated in vacuo. The crude residue was separated by flash column chromatography (CH2Cl2 to 5% CH3OH/CH2Cl2) to give 56 as white solid (1.58 g, 95%). 1H-NMR (360 MHz, CDCl3) δ 2.20-2.16 (m, 2H), 1.89-1.75 (m, 6H), 1.68 (br s, 4H), 1.57-1.54 (m, 2H), 1.48 (br s, 1H), 1.35 (s, 3H); 13C-NMR (90 MHz, CDCl3) δ 74.06, 39.30, 38.49, 35.33, 33.16, 27.73, 27.60, 27.22; ESI-MS: Calculated for C11H18O (M+H)+ 167.3. Found: 167.3.

Source