Réaction #710503

ord-09beeee2505841458329c4dc2d85ed28

Équation de réaction

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate
→
O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]
Sodium Citrate Citric Acid

Réactifs

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate

Réactifs

Aucun

Solvants

O
water
O
water

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    Autrereaction
  2. 2
    Autrefor the reaction
  3. 3
    AutreCarbon dioxide is evaporated rapidly
  4. 4
    Autrewater is gradually evaporated
  5. 5
    workup.ADDITIONa mixture of 87% Sodium citrate and 13% citric acid active ingredient
  6. 6
    AutreThe product is then dried
  7. 7
    Autrecrushed to fine particles
  8. 8
    Autreto produce an active composition suitable for formulation into the pharmacological formulations of this invention

Mode opératoire

Mix one part citric acid and one part sodium bicarbonate than gradually spray sterile water into the mixture to make reaction. The water is merely the medium for the reaction. Carbon dioxide is evaporated rapidly and water is gradually evaporated. The remaining product is a mixture of 87% Sodium citrate and 13% citric acid active ingredient. The product is in the form of crystals. The product is then dried and crushed to fine particles to produce an active composition suitable for formulation into the pharmacological formulations of this invention.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US09301935B2uspto-grants-2016_04