Réaction #710502

Équation de réaction

NaBH4

BF3

2-Chloro-3-[(E)-2-nitrovinyl]-6-(trifluoromethyl)pyridine

→

hydrochloride

Rendement 58.3%

2-[2-chloro-6-(trifluoromethyl)pyridin-3-yl]ethanamine

Solvants

HCl

tetrahydrofuran

tetrahydrofuran

Conditions de réaction

Traitement

1. 1
   AutreThe resulting reaction mixture
2. 2
   Autrewas allowed to room temperature
3. 3
   workup.ADDITIONwas added to above reaction mixture at room temperature
4. 4
   AutreThe resulting reaction mixture
5. 5
   Autrewas allowed to room temperature
6. 6
   workup.STIRRINGstirred for 16 h
7. 7
   AutreAfter completion of reaction
8. 8
   Autrethe reaction mixture was quenched in ice water (200 mL)
9. 9
   Extractionextracted with ethyl acetate (3×200 mL)
10. 10
    LavageThe combined organic layers were washed with water (1×100 mL), brine (1×100 mL)
11. 11
    Séchagedried over anhydrous sodium sulfate
12. 12
    Autrethe solvent was removed under reduced pressure
13. 13
    Autreto get crude amine
14. 14
    workup.STIRRINGstirred at room temperature for 2.0 h
15. 15
    ConcentrationThe reaction mixture was concentrated under reduced pressure

Mode opératoire

To a stirred solution of NaBH4 (16.0 g, 4.2 eq.) in tetrahydrofuran (125 mL) was added BF3 etherate (125 mL) at 0° C. The resulting reaction mixture was allowed to room temperature and stirred for 15 min 2-Chloro-3-[(E)-2-nitrovinyl]-6-(trifluoromethyl)pyridine (Int-19) (25.0 g, 1.0 eq) in tetrahydrofuran (125 mL) was added to above reaction mixture at room temperature. The reaction mixture was heated to 70° C. and stirred for 2 h. The resulting reaction mixture was allowed to room temperature and stirred for 16 h. The progress of the reaction was monitored by TLC. After completion of reaction, the reaction mixture was quenched in ice water (200 mL) and extracted with ethyl acetate (3×200 mL). The combined organic layers were washed with water (1×100 mL), brine (1×100 mL), dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure to get crude amine. The amine compound was dissolved in ethanolic HCl (50 mL) and stirred at room temperature for 2.0 h. The reaction mixture was concentrated under reduced pressure to get crude 2-[2-chloro-6-(trifluoromethyl)pyridin-3-yl]ethanamine (IIb-35) hydrochloride (15.0 g, 58.3%).

Source