Réaction #710466

Équation de réaction

1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride

EDC-HCl

dibromoacetic acid

→

2,2-dibromo-N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-acetamide

Rendement 15.0%

Solvants

dichloromethane

dichloromethane

Conditions de réaction

Traitement

1. 1
   Lavagewashed once with water and twice with a 1% HCl aqueous solution
2. 2
   Séchagedried over anhydrous magnesium sulfate
3. 3
   Concentrationconcentrated under reduced pressure
4. 4
   Autreto obtain the subject material
5. 5
   AutreAmount obtained 50 mg (yield 15%)

Mode opératoire

200 mg (0.78 mmol) of the 1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride obtained by the method described in another method of Synthetic Example P1, 238 mg (1.95 mmol) of DMAP and 224 mg (1.17 mmol) of EDC-HCl were dissolved in 10 ml of anhydrous dichloromethane, 101 μl (202 mg, 1.17 mmol) of dibromoacetic acid was added thereto, and the resulting mixture was stirred at room temperature overnight. After the reaction was completed, the reaction solution was diluted with dichloromethane, washed once with water and twice with a 1% HCl aqueous solution, and then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the subject material. Amount obtained 50 mg (yield 15%)

Source