Réaction #70638

Équation de réaction

Tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate

HCl

→

1-(trifluoromethyl)cyclopropylamine hydrochloride

Rendement 91.0%

Conditions de réaction

Traitement

1. 1
   Températureat reflux for 3.5 h
2. 2
   ConcentrationThe solution was concentrated in vacuo
3. 3
   Autrethe residue was triturated with acetone
4. 4
   AutreThe filtrate was collected
5. 5
   Concentrationconcentrated
6. 6
   Autrethe residue triturated with diethyl ether

Mode opératoire

Tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate (4.08 g, 18.3 mmol) was suspended in 1 N HCl(aq) (150 mL) and stirred at reflux for 3.5 h. The solution was concentrated in vacuo and the residue was triturated with acetone. The filtrate was collected, concentrated, and the residue triturated with diethyl ether to afford 2.67 g (91%) of 1-(trifluoromethyl)cyclopropylamine hydrochloride as a white solid.

Source