Réaction #70447

Équation de réaction

tert-butyl 4-[3-chloro-2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]-3,6-dihydro-2H-pyridine-1-carboxylate

tert-Butyl 4-[3-chloro-2-(4-methanesulfonylphenoxy-methyl)pyridin-5-yl]-3,6-dihydro-2H-pyridine-1-carboxylate

→

title compound

Rendement 26.0%

tert-Butyl 4-[3-chloro-2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidine-1-carboxylate

Rendement 26.0%

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   Filtrationfiltered through Celite pad
2. 2
   ConcentrationThe filtrate was concentrated under reduced pressure
3. 3
   AutreThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1)

Mode opératoire

To a solution of tert-butyl 4-[3-chloro-2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]-3,6-dihydro-2H-pyridine-1-carboxylate (Example 70) (50 mg, 0.104 mmol) in ethyl acetate (1 mL) was added platinum oxide (5 mg). The mixture was hydrogenated at room temperature for 4 hours and filtered through Celite pad. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1) to give the title compound as a white amorphous (13 mg, yield 26%).

Source