Réaction #7039

Équation de réaction

7-azaindole

butyraldehyde

→

1,1-di-(7-azaindol-3-yl)-butane

Rendement 15.0%

Conditions de réaction

Traitement

1. 1
   AutreST 1436 was prepared
2. 2
   AutreThe reaction
3. 3
   Températurehowever, was heated
4. 4
   Températureunder reflux for 48 hours
5. 5
   AutreThe end product was isolated
6. 6
   Autrepurified chromatographically on a silica column
7. 7
   Lavageeluting with a CH2Cl2

Mode opératoire

ST 1436 was prepared as described in example 2/2 from 7-azaindole and butyraldehyde. The reaction, however, was heated under reflux for 48 hours. The end product was isolated and purified chromatographically on a silica column eluting with a CH2Cl2:CH3COCH3 gradient ranging from 9:1 to 4:6. Yield 15%.

Source