Réaction #70336

Équation de réaction

tert-butyl 2-(5-fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoate

→

expected product

2-(5-Fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoic acid

Solvants

TFA

Conditions de réaction

Traitement

1. 1
   Autrethe crude mixture was purified by reverse phase chromatography
2. 2
   Autreaffording

Mode opératoire

A solution of tert-butyl 2-(5-fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoate (0.83 mmol, 0.313 g) in TFA (5 ml) was stirred at room temperature for 30 minutes. The solvent was reduced under reduced pressure and the crude mixture was purified by reverse phase chromatography using a 30% to 100% (Water-ACN) gradient and affording 0.119 g (40% of yield) of the expected product.

Source