Réaction #69939

Équation de réaction

10-oxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione

PCl5

→

5-chloro-10-oxa-tricyclo[5.2.1.0*2,6*]dec-4-en-3-one

Rendement 139.7%

Solvants

chloroform

Conditions de réaction

Traitement

1. 1
   Températureheated
2. 2
   Températureat reflux for 5 hours
3. 3
   AutreThe reaction mixture is evaporated to dryness
4. 4
   AutreThe crude product is purified by flash chromatography

Mode opératoire

To a solution of 10-oxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione (1.66 g, 10 mmol) in chloroform (20 ml) is added PCl5 (1.04 g, 5 mmol) in one portion. The reaction mixture is stirred and heated at reflux for 5 hours. The reaction mixture is evaporated to dryness. The crude product is purified by flash chromatography to give 5-chloro-10-oxa-tricyclo[5.2.1.0*2,6*]dec-4-en-3-one (1.29 g).

Source