Réaction #698778

Équation de réaction

ethyl bromopyruvate

2-imino-4-thiobiuret

→

ethyl 2-guanidino-thiazole-4-carboxylate hydrobromide

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Températurethe reaction mixture is heated
2. 2
   Températureunder reflux for 3 hours (J. Med. Chem. 34, 914-918 (1991))
3. 3
   Autrethe reaction product is precipitated by the addition of 550 ml of ethyl acetate
4. 4
   Filtrationfiltered off

Mode opératoire

13.9 ml of ethyl bromopyruvate are added to a solution of 11.81 g of 2-imino-4-thiobiuret (Aldrich) in 100 ml of ethanol and the reaction mixture is heated under reflux for 3 hours (J. Med. Chem. 34, 914-918 (1991)). Subsequently, the mixture is cooled to room temperature and the reaction product is precipitated by the addition of 550 ml of ethyl acetate and filtered off. There are obtained 14.6 g of yellowish ethyl 2-guanidino-thiazole-4-carboxylate hydrobromide. MS: 214 (M)+.

Source