Réaction #696703

Équation de réaction

4-Vinylbenzyl chloride

Ethyl acetoacetate

sodium ethoxide

→

ethyl 2-(4-vinylbenzyl)-3-oxobutanoate

Rendement 95.0%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Températurewas cooled in an ice-water bath
2. 2
   TempératureThe mixture was refluxed for 16 hours
3. 3
   Filtrationthe resulting slurry was filtered
4. 4
   Autreto remove any salt
5. 5
   Autrethe solution collected
6. 6
   AutreThe solvent was removed under reduced pressure

Mode opératoire

Ethyl acetoacetate (27.61 g, 0.21 mol) was dissolved in ethanol (100 ml) which was cooled in an ice-water bath, and sodium ethoxide (15.59 g, 0.22 mol) was added. 4-Vinylbenzyl chloride (33.92 g, 0.2 mole) was added. The mixture was refluxed for 16 hours, then the resulting slurry was filtered to remove any salt, and the solution collected. The solvent was removed under reduced pressure to give ethyl 2-(4-vinylbenzyl)-3-oxobutanoate in the form of a light red liquid (49 g) in 95% yield.

Source