Réaction #69387

Équation de réaction

3-phenylthio-phtalic acid

acetic anhydride

→

3-phenylthio-phtalic anhydride

Rendement 74.8%

Conditions de réaction

Traitement

1. 1
   Températureto reflux for 6 hours
2. 2
   workup.WAITUpon standing over night
3. 3
   Autre3-phenylthio-phtalic anhydride precipitated from the medium

Mode opératoire

25.6 g (93.5 mmol) 3-phenylthio-phtalic acid and 26.4 mL (281 mmol) acetic anhydride were heated to reflux for 6 hours. The reaction mixture was allowed to cool down to room temperature. Upon standing over night, 3-phenylthio-phtalic anhydride precipitated from the medium. A first crop of 16.8 g of 3-phenylthio-phtalic anhydride was isolated by filtration and dried. The filtrate was evaporated to half of its volume and a second crop of 4.1 g of 3-phenylthio-phtalic anhydride was isolated. 20.9 g (87%) of 3-phenylthio-phtalic anhydride was isolated (m.p. 148-50° C.)

Source