Réaction #69311

ord-38105208dc174948be05afc2d2b82921

Équation de réaction

COc1ccc2[nH]c3c(c2c1)CC1(C)C(=O)N(CCBr)C(=O)N1C3c1cccc(O)c1
(3aSR,10RS)-2-(2-Bromoethyl)-10-(3-hydroxy-phenyl)-6-methoxy-3a-methyl-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]-fluorene-1,3-dione
CC(=O)N1CCNCC1
N-acetyl piperazine
→
COc1ccc2[nH]c3c(c2c1)CC1(C)C(=O)N(CCN2CCN(C(C)=O)CC2)C(=O)N1C3c1cccc(O)c1
title compound
COc1ccc2[nH]c3c(c2c1)CC1(C)C(=O)N(CCN2CCN(C(C)=O)CC2)C(=O)N1C3c1cccc(O)c1
(3aSR,10RS)-2-[2-(4-Acetyl-piperazin-1-yl)-ethyl]-10-(3-hydroxy-phenyl)-6-methoxy-3a-methyl-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione

Réactifs

COc1ccc2[nH]c3c(c2c1)CC1(C)C(=O)N(CCBr)C(=O)N1C3c1cccc(O)c1
(3aSR,10RS)-2-(2-Bromoethyl)-10-(3-hydroxy-phenyl)-6-methoxy-3a-methyl-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]-fluorene-1,3-dione
CC(=O)N1CCNCC1
N-acetyl piperazine

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The title compound is prepared similarly as described for example 29 using (3aSR,10RS)-2-(2-Bromoethyl)-10-(3-hydroxy-phenyl)-6-methoxy-3a-methyl-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]-fluorene-1,3-dione (example 24) and N-acetyl piperazine as starting materials. MS: m/z (MH+)=532.1

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08530493B2uspto-grants-2013_09