Réaction #691937

Équation de réaction

pentafluorobenzenesulfonyl chloride

ammonium chloride

sodium hydroxide

→

pentafluorobenzenesulfonamide

Rendement 36.0%

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   FiltrationThe precipitated product was filtered
2. 2
   Autrerecrystallized from toluene

Mode opératoire

Under room temperature, a solution of 468 g of pentafluorobenzenesulfonyl chloride in acetone was added dropwise to an aqueous solution containing 964 g of ammonium chloride, during which a pH was adjusted to 7 with an aqueous sodium hydroxide solution. The precipitated product was filtered, and recrystallized from toluene to obtain 156 g of pentafluorobenzenesulfonamide as white crystals. A structure was confirmed by 1H-NMR, 19F-NMR and IR.

Source