Réaction #68621

Équation de réaction

N-ethyl-N-isopropylpropan-2-amine

2,5-dibromothiazole

dimethylamine

→

solid

Rendement 29.4%

5-bromo-N,N-dimethylthiazol-2-amine

Rendement 29.4%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   AutreThe vial was sealed
2. 2
   Concentrationwas concentrated
3. 3
   Autrepurified by MPLC (
4. 4
   Lavageeluted with a gradient of 0-50% ethyl acetate in hexanes)

Mode opératoire

To a microwave vial was added N-ethyl-N-isopropylpropan-2-amine (0.72 mL, 4.1 mmol), 2,5-dibromothiazole (1.00 g, 4.1 mmol) and dimethylamine (40% in water, 0.52 mL, 4.1 mmol) in ethanol (10 mL). The vial was sealed and stirred at 140° C. under microwave irradiation for one hour, then was concentrated and purified by MPLC (eluted with a gradient of 0-50% ethyl acetate in hexanes) to yield the product as a white, crystalline solid (0.25 g, 29%).

Source