Réaction #684975

Équation de réaction

ethyl acetate

Potassium carbonate

methyl iodide

compound

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

→

title compound

Rendement 84.4%

2-(4-Bromo-2-fluorobenzyl)-3-methoxypyridine

Rendement 84.4%

Solvants

dimethylformamide

Conditions de réaction

Traitement

1. 1
   Lavagethe reaction mixture was washed with saturated brine
2. 2
   Concentrationconcentrated under reduced pressure
3. 3
   AutreThe residue was purified by silica gel column chromatography

Mode opératoire

Potassium carbonate (38.7 mg, 0.280 mmol) and methyl iodide (10.5 μl, 0.168 mmol) were added to a solution of the compound of Example B245 (15.8 mg, 0.0560 mmol) in dimethylformamide (1 ml), and this reaction mixture was stirred at room temperature for 2 hours. After ethyl acetate was added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (14.0 mg).

Source