Réaction #684974

Équation de réaction

ethyl acetate

Trifluoroacetic acid

compound

2-(4-Bromo-2-fluorobenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

→

title compound

Rendement 84.1%

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

Rendement 84.1%

Solvants

methylene chloride

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas added
2. 2
   LavageThe ethyl acetate layer was washed with saturated brine
3. 3
   Concentrationconcentrated under reduced pressure
4. 4
   AutreThe residue was purified by silica gel column chromatography

Mode opératoire

Trifluoroacetic acid (1 ml) was added to the compound of Example B244 (134 mg, 0.411 mmol) in methylene chloride (4 ml), and this reaction mixture was stirred at room temperature overnight. After neutralizing the mixture with saturated aqueous sodium hydrogencarbonate, ethyl acetate was added. The ethyl acetate layer was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (97.5 mg).

Source