Réaction #684970

Équation de réaction

Potassium carbonate

methyl iodide

compound

1-(4-Bromo-2-hydroxyphenyl)-1-butanone

→

title compound

Rendement 67.7%

1-(4-Bromo-2-methoxyphenyl)-1-butanone

Rendement 67.7%

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   Températurewhile heating
2. 2
   Températureunder reflux for 4 hours
3. 3
   FiltrationThe reaction mixture was filtered through celite, ether
4. 4
   workup.ADDITIONwas added
5. 5
   Autreto remove insoluble material
6. 6
   Filtrationby filtration
7. 7
   Concentrationthe filtrate was concentrated under reduced pressure
8. 8
   AutreThe residue was purified by silica gel column chromatography

Mode opératoire

Potassium carbonate (9.07 g) and methyl iodide (3.92 ml) were added to a solution of the compound of Example B220 (13.30 g) in acetone (75 ml), and this reaction mixture was stirred while heating under reflux for 4 hours. The reaction mixture was filtered through celite, ether was added to remove insoluble material by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (9.52 g).

Source