Réaction #684969

Équation de réaction

Water

ethyl acetate

1-hydroxyisoquinoline

Bromine

→

title compound

Rendement 80.1%

4-Bromo-1-isoquinolinol

Rendement 80.1%

Solvants

tetrahydrofuran

acetic acid

Conditions de réaction

Traitement

1. 1
   Autrethe resulting reaction mixture
2. 2
   Filtrationwas filtered
3. 3
   Filtrationthrough filter paper
4. 4
   LavageThe organic layer was washed with saturated brine
5. 5
   Concentrationconcentrated under reduced pressure
6. 6
   AutreThe residue was recrystallized from ethyl acetate and hexane

Mode opératoire

Bromine (1.78 ml, 34.5 mmol) was added to an ice-cooled solution of 1-hydroxyisoquinoline (5.01 g, 34.5 mmol) in acetic acid (50 ml), and this reaction mixture was stirred at room temperature for 2 hours. Water, ethyl acetate, and tetrahydrofuran were added, and the resulting reaction mixture was filtered through filter paper. The organic layer was washed with saturated brine and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate and hexane to give the title compound (6.19 g).

Source