Réaction #684965

Équation de réaction

hydrobromic acid

compound

1-(4-Butylbenzyl)-6-methoxyisoquinoline

→

title compound

Rendement 94.6%

1-(4-Butylbenzyl)-6-isoquinolinol

Rendement 94.6%

Conditions de réaction

Traitement

1. 1
   Températureunder reflux for 19 hours
2. 2
   ConcentrationThe mixture was concentrated under reduced pressure, water
3. 3
   workup.ADDITIONwas added
4. 4
   Autreto precipitate crystals
5. 5
   FiltrationThe obtained crystals were collected by filtration
6. 6
   Lavagewashed with water
7. 7
   Autredried

Mode opératoire

A 47% hydrobromic acid solution was added to the compound of Example B146 (82 mg), and the mixture was stirred under reflux for 19 hours. The mixture was concentrated under reduced pressure, water was added, and the resulting mixture was neutralized with sodium carbonate to precipitate crystals. The obtained crystals were collected by filtration, washed with water, and then dried to give the title compound (74 mg).

Source