Réaction #684964

Équation de réaction

Phosphorus oxychloride

compound

N-[2-Hydroxy-2-(3-methoxyphenyl)ethyl]-2-(4-butylphenyl)-acetamide

sodium hydrogencarbonate

→

title compound

Rendement 15.8%

1-(4-Butylbenzyl)-6-methoxyisoquinoline

Rendement 15.8%

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   Températureunder reflux for 1 hour 30 minutes
2. 2
   TempératureThe mixture was cooled on ice
3. 3
   Extractionextracted with ethyl acetate
4. 4
   Séchagedried over anhydrous magnesium sulfate
5. 5
   Concentrationconcentrated under reduced pressure
6. 6
   AutreThe residue was purified by silica gel column chromatography

Mode opératoire

Phosphorus oxychloride (1.6 ml) was added to a solution of the compound of Example B145 (600 mg, 1.7 mmol) in acetonitrile (15 ml), and the mixture was stirred under reflux for 1 hour 30 minutes. The mixture was cooled on ice, made alkaline with a 5% aqueous sodium hydrogencarbonate solution, extracted with ethyl acetate, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (82 mg).

Source