Réaction #684962

Équation de réaction

ammonium formate

compound

1-(3-Methoxyphenyl)-2-nitro-1-ethanol

→

title compound

Rendement 72.6%

2-Amino-1-(3-methoxyphenyl)-1-ethanol

Rendement 72.6%

Solvants

tetrahydrofuran

methanol

Conditions de réaction

Traitement

1. 1
   AutreThe catalyst was removed by filtration
2. 2
   workup.ADDITIONthe filtrate was diluted with ether
3. 3
   Autreprecipitates
4. 4
   Autrewere removed by filtration
5. 5
   Concentrationthe obtained filtrate was concentrated

Mode opératoire

Palladium-carbon (10%, 0.64 g) and ammonium formate (4.8 g) were added to a mixed solution of the compound of Example B142 (3.0 g, 15 mmol) in tetrahydrofuran (43 ml) and methanol (43 ml), and this mixture was stirred at room temperature for 18 hours. The catalyst was removed by filtration, the filtrate was diluted with ether, precipitates were removed by filtration, and the obtained filtrate was concentrated to give the title compound (1.82 g). This compound was used in the following reaction without further purification.

Source