Réaction #684952

Équation de réaction

sodium hydrogencarbonate

Methanesulfonyl chloride

triethylamine

o-iodobenzyl alcohol

→

title compound

Rendement 100.7%

1-(Chloromethyl)-2-iodobenzene

Rendement 100.7%

Solvants

methylene chloride

Conditions de réaction

Traitement

1. 1
   Extractionthe resulting mixture was extracted with methylene chloride
2. 2
   SéchageThe methylene chloride layer was dried over anhydrous magnesium sulfate
3. 3
   Concentrationconcentrated under reduced pressure

Mode opératoire

Methanesulfonyl chloride (2.0 ml, 29 mmol) and triethylamine (3.6 ml, 26 mmol) were added to a solution of o-iodobenzyl alcohol (5.0 g, 21 mmol) in methylene chloride (50 ml) cooled to 0° C., and the mixture was stirred at that temperature for 19 hours. A 5% aqueous sodium hydrogencarbonate solution was added, and the resulting mixture was extracted with methylene chloride. The methylene chloride layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the title compound (5.34 g).

Source