Réaction #68393

Équation de réaction

ethyl2-tert-butyl-3-(3,4-difluorobenzylcarbamoyl)-1H-indole-6-carboxylate

Compound 115

ethyl2-tert-butyl-3-(3,4-difluorobenzylcarbamoyl)-1H-indole-6-carboxylate

benzyl bromide

K2CO3

→

title compound

Ethyl 1-Benzyl-2-tert-butyl-3-(3,4-difluorobenzylcarbamoyl)-1H-indole-6-carboxylate

Solvants

DMF

EtOAc

Conditions de réaction

Traitement

1. 1
   Lavagewashed with H2O and brine
2. 2
   Séchagedried over Na2SO4
3. 3
   Concentrationconcentrated in vacuo
4. 4
   AutreThe residue was purified by chromatography on silica gel (0→30% EtOAc-hexanes)

Mode opératoire

To a solution of ethyl2-tert-butyl-3-(3,4-difluorobenzylcarbamoyl)-1H-indole-6-carboxylate (Compound 115, 33 mg, 0.080 mmol) in DMF (1 ml) was added benzyl bromide (47 μl, 0.40 mmol) and K2CO3 (33 mg, 0.24 mmol). The mixture was stirred at room temperature for 24 h, diluted with EtOAc, washed with H2O and brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→30% EtOAc-hexanes) followed by PTLC (5% MeOH—CH2Cl2) to yield the title compound.

Source