Réaction #683031

Équation de réaction

4-fluoropyridin-2-amine

NBS

→

5-bromo-4-fluoropyridin-2-amine

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   Autrethe reaction complete
2. 2
   AutreAfter quenched with sat Na2S2O3 and NaHCO3
3. 3
   workup.STIRRINGstirred for 30 min
4. 4
   ExtractionThe reaction mixture was extracted with EtOAc 3 times
5. 5
   LavageWashed
6. 6
   AutreDried
7. 7
   Concentrationconcentrated
8. 8
   AutreThe crude material was triturated with ether
9. 9
   Autretaken to the next step without further purification
10. 10
    Autre192.9 (MH+), 0.32 min.

Mode opératoire

To a solution of 4-fluoropyridin-2-amine (400 mg, 3.57 mmol) in acetonitrile (35. 7 mL) was added NBS (648 mg, 3.64 mmol) in three portions at 0° C. The reaction mixture was stirred at 0° C. for 20 min. LCMS showed the reaction complete. After quenched with sat Na2S2O3 and NaHCO3, stirred for 30 min. The reaction mixture was extracted with EtOAc 3 times. Washed by sat NaHCO3, water and brine. Dried and concentrated. The crude material was triturated with ether and taken to the next step without further purification. LCMS (m/z): 192.9 (MH+), 0.32 min.

Source