Réaction #67962

Équation de réaction

1-tert-butyl 3-ethyl 4-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl)piperazine-1,3-dicarboxylate

hydrogen chloride ethanol

water

→

ethyl 1-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl)piperazine-2-carboxylate

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   Autrethe solvent was removed under reduced pressure
2. 2
   AutreThe residue thus obtained
3. 3
   AutreThe aqueous layer was separated
4. 4
   workup.ADDITIONethyl acetate was added
5. 5
   AutreThe organic layer was separated
6. 6
   Séchagedried over potassium carbonate
7. 7
   Autrethe solvent was removed under reduced pressure

Mode opératoire

To 0.60 g of 1-tert-butyl 3-ethyl 4-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl)piperazine-1,3-dicarboxylate, 12 mL of 10 mol/L hydrogen chloride/ethanol was added, and the mixture was stirred for 2 hours, and then the solvent was removed under reduced pressure. The residue thus obtained was added with water and ethyl acetate. The aqueous layer was separated, ethyl acetate was added thereto, and the resultant solution was adjusted to pH 14 with a 5 mol/L aqueous sodium hydroxide solution. The organic layer was separated and dried over potassium carbonate, and the solvent was removed under reduced pressure to obtain 0.34 g of a brown oily substance, ethyl 1-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl)piperazine-2-carboxylate.

Source