Réaction #6790

Équation de réaction

4,4,4-trifluoro-1-[4-(methylthio)phenyl]butane-1,3-dione

2-methyl-2-thiopseudourea sulfate

sodium acetate

→

title compound

Rendement 96.2%

2-(Methylthio)-4-[4-(methylthio)phenyl]-6-(trifluoromethyl)pyrimidine

Rendement 96.2%

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Températureheated
2. 2
   Températureunder reflux for 8 h
3. 3
   ConcentrationThe mixture was concentrated in vacuo and water (100 ml)
4. 4
   workup.ADDITIONadded
5. 5
   Autreto give a solid
6. 6
   Autrewhich was isolated by filtration

Mode opératoire

To a mixture of 4,4,4-trifluoro-1-[4-(methylthio)phenyl]butane-1,3-dione (5 g) and 2-methyl-2-thiopseudourea sulfate (5.1 g, 0.98 eq) in acetic acid (100 ml) was added sodium acetate (3 g, 2 eq) and heated under reflux for 8 h. The mixture was concentrated in vacuo and water (100 ml) added to give a solid, which was isolated by filtration to give the title compound as a yellow solid (5.8 g, quantitative).

Source