Réaction #6782

Équation de réaction

4-carboxyindole

2-chloro-1-methylpyridinium iodide

4-phenethylpiperazine

ethyldi-isopropylamine

→

(1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride

Rendement 100.1%

Solvants

acetone

N-methylpyrrolidone

NMP

Conditions de réaction

Traitement

1. 1
   Autrethe crude product is obtained
2. 2
   Autrethe hydrochloride is precipitated
3. 3
   AutreAfter drying

Mode opératoire

A solution of 2.0 g of 4-carboxyindole and 8.1 g of 2-chloro-1-methylpyridinium iodide in 60 ml of N-methylpyrrolidone (NMP) is treated with a solution of 2.36 g of 4-phenethylpiperazine and 8.2 g of ethyldi-isopropylamine (EDIPA) in 20 ml of NMP and subsequently stirred at room temperature for 3 hours. The mixture is worked up in the customary manner and the crude product is obtained. This is dissolved in acetone and the hydrochloride is precipitated using aqueous hydrochloric acid. After drying, 4.59 g of (1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride, m.p. 289.3°, is obtained.

Source